Ponce De Leon, FL is a city located in Holmes County, Florida and has a land area of 225.80 square miles (584.82 km2). The water area for the city is 8.31 square miles or 21.52 km2. There is one unique zip code in Ponce De Leon, Florida and it is 32455. The area code(s) for Ponce De Leon is 850.
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